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"As patients understand more about managing toxicity, they can take better care of themselves and be prepared to ask their healthcare team the right questions to increase their quality of life." The book stresses that immune-related adverse events can start at any point during or after immunotherapy

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At the genomic level, Epitalon modulated the expression of key circadian rhythm genes: Clock expression in leukocytes decreased 1.8-fold, Cry2 expression doubled, and Csnk1e expression in lymphocytes decreased by 2.1-fold, all with statistical significance

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