glp 1 analogue mechanism of action GLP-1 Analogues in the Neurobiology Addiction: Translational Insights and Therapeutic Perspectives glp-1_analogs [TUSOM | Pharmwiki]

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105,106,107 Notably, not all interactions with ER-resident E3 ubiquitin ligases result in their degradation, exemplified by p62 ubiquitination by RNF26, 108,109 suggesting possible translocation of noncanonical ubiquitinated substrates as a possible mechanism for ERAD recognition

And what trade-offs should be part of that conversation