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There are also serious side effects that can happen, but are rare, which can include: pancreatitis, medullary thyroid cancer, acute kidney injury and worsening diabetes-related retinopathy

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Hiraoka A, Yoshiji H, Iwasa M, Nakanishi H, Karino Y, Nakajima T, et al

On a therapeutic note, some microbiota-targeted treatments have reduced protein aggregates in models: long-term broad-spectrum antibiotics reduced A deposition and microglial reactivity in an AD mouse model, and recolonization with a simplified microbiota reversed some of these effects, indicating that specific microbial communities can either exacerbate or ameliorate protopathic cascades [102]