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J Biol Chem 278:2249222497 Conticello C, Martinetti D, Adamo L, Buccheri S, Giuffrida R, Parrinello N, Lombardo L, Anastasi G, Amato G, Cavalli M et al (2012) Disulfiram, an old drug with new potential therapeutic uses for human hematological malignancies
The serious risks (allergic reactions, liver effects) are associated mainly with high-dose, unregulated IV use, which is why medical supervision and sensible dosing matter
In March 2025 it will be a year since the Nice Guideline on B12 Deficiency in over 16s was published
Setmelanotide, while mechanistically rational, lacks confirmatory trial data specifically for MC4R -deficient obesity and should be regarded as an exploratory option at present
Oncotarget (2017) 8:8594968
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