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Trong trng hp GSH khng c ti ch, c th s i mt vi tnh trng qu ti cht c, dn n mt cn bng v nh hng n sc khe

Increased levels of free fatty acids and pro-inflammatory cytokines synergistically trigger tissue-level desensitization to insulin (53, 5560)

Later meta-analyses also report small but significant reductions in body weight, BMI or fat mass, with effects more relevant in overweight or obese populations