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Kenneth McCall, published a paper in 2025 finding that compounded GLP-1s were linked to higher rates of adverse effects than non-compounded products between 2018 and 2024, including more abdominal pain, diarrhea, and nausea

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It stimulates neurons in the hypothalamus to release gonadotropin releasing hormone, which then signals the pituitary gland to produce both LH and FSH