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This non-peptide mechanism, elucidated through cryo-electron microscopy and published in the Proceedings of the National Academy of Sciences in 2020, overturned decades of pharmacological dogma that class B GPCRs could only be meaningfully activated by peptide ligands

Warburg effect induces lactate accumulation, which serves as a metabolic end-product and intercellular signaling mediator within the tumor microenvironment (TME)

Biol Plant 55:125132

Berberine has shown promise in some trials for improving glycaemic control in type 2 diabetes, with mechanisms possibly involving improved insulin sensitivity and altered gut microbiota

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