With FDA coverage for chronic kidney disease, obstructive sleep apnea, metabolic-associated liver disease, and cardiovascular diseases, the percentage of people who might benefit from a GLP-1 continues to expand
Prokinetic agents like metoclopramide present a theoretical option but should be used cautiously given potential adverse effects (including tardive dyskinesia with use beyond 12 weeks) and the counterintuitive nature of accelerating gastric emptying while using a medication that intentionally slows it
23,33 In one study, compared with 30-year-old men, 50-year-old men had a 22% lower sperm volume, 37% reduced sperm motility, and 18% fewer morphologically normal sperm
Treatment should complement rather than replace lifestyle modifications, with multidisciplinary support including dietetic input, psychological support, and regular medical monitoring essential for optimal outcomes
One of these hormones is GLP-1 (glucagon-like peptide-1)