Taken together, it has been proposed that muscle loss during GLP-1 RAs-based therapy is largely adaptive and proportional to overall weight reduction, and that improvements in muscle quality and insulin sensitivity may help offset potential functional decline [97]
In preclinical trials on research subjects, this synthetic peptide has only shown promising benefits in affecting patterns linked with fat metabolism
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In a randomised, placebo-controlled double blinded phase 1 study of ascending single doses in healthy overweight humans, cotadutide was shown to be safe and, in common with the GLP-1 analogues, to be associated with dose-dependent gastrointestinal adverse events especially nausea and vomiting
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