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Unlike exenatide, which is derived from exendin-4, semaglutide is a synthetic analog of human GLP-1, engineered for a significantly longer half-life and greater potency.[119] Although both drugs fall under the same therapeutic class, their differing pharmacological profiles illustrate how follow-on biopharmaceutical innovation can enhance clinical efficacy, usability, and patient reach over time
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10.1111/j.1572-0241.2003.07591.x 32 FordA
Tesamorelin is more effective for targeting visceral fat reduction, particularly in the abdominal area, whereas sermorelin supports overall fat metabolism but is not as directly potent for fat loss
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