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As described in section A Model for Changes in MRS Measured Glutamate, GABA, and Glutamine Levels During the Progression of ALS, elevated extracellular glutamate due to both enhanced neuronal release and impaired glial reuptake plays a key role in theories of the pathogenesis of ALS
However, in circumstances of high stress, environmental pollution or gastrointestinal problems, an undersupply can emerge
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