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This neurodegeneration is accompanied by the formation of characteristic Lewy bodies, which are intracellular inclusions composed largely of aggregated and misfolded -synuclein ( This degeneration of dopaminergic neurons is strongly linked to the generation of reactive oxygen species and oxidative stress as well as mitochondrial dysfunction, neuroinflammation, and aging (Smeyne and Smeyne, 2013)
A significant link between ferroptosis and the development of various cardiovascular conditions has been reviewed [148]
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The exact molecular mechanisms and functional consequences of TG2-mediated modification of cellular GSTP1 need to be further investigated
