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After release of TML by lysosomal protein degradation, this compound is hydroxylated by TMLD, after which the resulting HTML is cleaved by a specific aldolase, which uses pyridoxal 5-phosphate (PLP) as a cofactor, into TMABA and glycine Substrate and Intermediate Compounds Trimethyllysine (TML) TML is the starting substrate for carnitine biosynthesis, derived from the methylation of lysine residues in proteins

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This molecular similarity can trigger the autoimmune attack on thyroid tissue that characterises Hashimotos thyroiditis

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This change follows the FDAs 2025 declaration that drug shortages for these medications have been resolved

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However, keep in mind that these studies evaluate the effects of highly concentrated amla extract doses rather than amla juice itself

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