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Washington, DC: Taylor & Francis

It is possible that additional satiety signals, such as glutamate 40 , GABA 41 , cholecystokinin (CCK) 42 , pro-opiomelanocortin (POMC) 43 , neuropeptide Y 44 , and/or norepinephrine 44 , are mediating the macronutrient-dependent feeding responses associated with NTS neuron activation

Minimize Side Effects: Starting low helps the research model adapt to the new compound, potentially reducing the incidence or severity of acute gastrointestinal side effects (like nausea or decreased appetite) that can occur with GLP-1 and GIP receptor agonists

Approximately 7-8 days, supporting once-weekly research protocols