Although it has been established that NEPs can degrade GLP-1(736)NH 2 and (936)NH 2 in vitro [11, 39, 40], we can now show that this occurs (in vivo) in mice with extreme rapidity and independent of DPP-4, consistent with the recent finding that NEP 24.11 knockout mice have higher plasma levels of GLP-1 [41] and that NEP 24.11 is ubiquitously expressed in endothelial cells [42]
However, patients should be aware that allulose is still counted in total carbohydrates on nutrition labels, which may be relevant for carbohydrate counting
Important safety information and common side effects Do not use with other GLP-1 receptor agonist medications, or any other products containing GLP-1s
10.1089/thy.2008.0371 83 KebebewE.PengM.ReiffE.TreselerP.WoeberK
Originally developed for type 2 diabetes, these drugs are now used off-label for PCOS treatment due to their ability to regulate appetite, improve blood sugar levels, and promote weight loss