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SELENOP: selenoprotein P
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In addition, activation of GLP-1Rs has anti-inflammatory effects via stimulation of AMPK, cAMP, endothelial nitric oxide synthase (eNOS), and suppression of chemokine expression (Jin and Liu 2020)
The percentages of participants who experienced AE leading to treatment discontinuation as well as of those who experienced gastrointestinal AE with oral semaglutide 50 mg (Tables 2 and 3) were similar to those observed with subcutaneous semaglutide 2.4 mg (in STEP-1 and STEP-2 trials 67% discontinued treatment due to AE, 3444% experienced nausea, 2132% diarrhoea and 2225% vomiting) [11, 29]
