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Inhibition of pyroptosis: blocking the NLRP3 inflammasome activation cascade During renal I/R, a surge in ROS can trigger NLRP3 inflammasome assembly

By reducing IGFBP-3 binding, more of the administered peptide reaches IGF-1 receptors as free, biologically active ligand

Insulin resistance-mediated dysregulation of carnitine transport Beyond direct transport defects, systemic insulin resistance in DKD significantly exacerbates carnitine metabolic imbalance

5-HETE, a 15-HETE precursor or PGE2) was able to promote the production of IL-6 or CXCL1 in our model (Supplementary Fig

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