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The presence of high concentrations of tyrosine in the locus coeruleus and the substantia nigra leads to increased melanin synthesis which confers on these brain regions a dark bluish coloration observable in brain sections

10.1016/0014-2999(83)90327-8 Warter JM, Brandt C, Marescaux C, Rumbach L, Micheletti G, Chabrier G, Krieger J, Imler M: The renal origin of sodium valproate-induced hyperammonemia in fasting humans

As an agonist at amylin and calcitonin receptors, cagrilintide is being investigated for its effect on appetite, food intake, and bodyweight, and it is engineered for a duration that supports once-weekly subcutaneous dosing

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