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The dose escalation design tested different starting doses (2 mg vs 4 mg) to evaluate tolerability
Purity and contamination: supplied material may not match its label or may contain other substances
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a single dose methylcobalamin of 1500 mcg in patients with peripheral neuropathy
Cases of progressive gait instability and loss of balance have been documented in patients taking extremely high doses for extended periods, with symptoms in some instances proving irreversible
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