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Exendin-4, a GLP-1 receptor agonist similar to the GLP-1 component of tirzepatide, suppressed water intake in rats for more than 4 hours after administration
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Since none of the GLP-1RA are approved in pregnancy, a cohort study approved the potency of liraglutide, in early pregnancy, despite its adverse outcomes such as preterm birth, preeclampsia and gestational diabetes mellitus (GDM) (90)
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