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Although, the precise mechanism of ketamine action is elusive, various studies have reported that acute intervention with a low dose of ketamine increases glutamate efflux in PFC of mice and rats (112, 175, 176)

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Lai EC, Felice KJ, Festoff BW, Gawel MJ, Gelinas DF, Kratz R, Murphy MF, Natter HM, Norris FH, Rudnicki SA: Effect of recombinant human insulin-like growth factor-I on progression of ALS

105 It suppresses the biological activity of skin cells and the expression of cytokines, resulting in immune dysfunction of the wound, dysplasia of granulation tissue, and reepithelialization disorders, thus delaying wound healing