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Starting with lower doses and titrating up gradually reduces this occurrence

10.1111/nph.12304 New Phytol

Myotendinous Junction Repair (Japjec et al., 2021) In myotendinous-junction injuries, BPC-157 led to full defect closure and functional restoration within six weeks, normalizing nitric-oxide pathways and revascularization

Similarly, niacinamide concentrations should not exceed 10% for periorbital use versus 15-20% sometimes used on face, and retinoids if included should be present only in gentle forms at low concentrations to avoid significant irritation

Patients with any active cancer or personal history of cancer (particularly hormone-sensitive cancers) are not candidates for Epitalon without specialist oncological clearance