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GLP-1 receptor agonists should be initiated at the lowest recommended dose and increased gradually according to the product-specific prescribing schedule

Major adverse effects include hypoglycemia (dose-and timing-dependent, potentially life-threatening), hypokalemia, local injection-site reactions, lipodystrophy, and the rare development of anti-insulin antibodies leading to insulin resistance

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This was demonstrated by investigations of gene and protein expression, morphology, and migration

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