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Some researchers report reliable potency up to 45 days, but 28 days is the conservative window supported by stability data

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But the brain, muscles, and immune system, which are the highest energy consumers, show the most dramatic functional consequences

in the Journal of Pharmacology and Experimental Therapeutics (which established Dihexas HGF/c-Met mechanism via Morris water maze rescue with HGF antagonist blockade) was the subject of an Expression of Concern in 2021 and was formally retracted in April 2025 by the publishing journal following investigation into image manipulation