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Also, it increases the death of GLP-1-producing cells through increased ceramide production, caspase-3 activity, and DNA fragmentation [140]

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To assess the effect of GIPR antagonism on GIP-induced c-Fos activation in the AP, mice were pre-treated with IP IgG1, mGIPR-Ab or mGIPR-Ab/P3, followed 24 h later by IP vehicle or [D-Ala 2 ]-GIP (DA-GIP

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