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It communicates with multiple organs, including the brain, pancreas, stomach, and digestive system to help regulate hunger, blood sugar, and energy balance
Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans
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Brain energy homeostasis Impaired insulin signalling in the brain has been strongly associated with AD and other dementias.22 GLP-1RAs that enter the CNS have been proposed to locally improve insulin sensitivity, thus restoring energy balance within neural circuits and reducing hyperglycaemic toxicity as observed in preclinical models.9 10 23 In humans, evidence for this mechanism was obtained in a 6-month randomised placebo-controlled trial of 38 people with AD, where liraglutide prevented the decline of glucose metabolism24 and restored glucose transport at the BBB25 as measured with [ 18 F]Fluorodeoxyglucose positron emission tomography (PET)see also ref 26
The most common adverse events were nausea, constipation, diarrhea, and vomiting, with more cases reported in both treatment arms versus their respective placebo arms
