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Week 4: Minor changes
It downregulates the expression of pro-inflammatory factors: GSDMD, NLRP3, IL-1, IL-18 and Caspase-1 in vivo , and blocks renal inflammation driven by NF-B and renal fibrosis mediated by TGF-/Smad3 through blocking the Smad7 degradation pathway mediated by Smurf2, preventing apoptosis of renal tubular epithelial cells through regulating the TXNIP-NLRP3-GDMD axis in vitro
It is not a prohibited substance under Wada rules
Thus, RyR2 would not be expected to bind atorvastatin in this region or would only do so with much lower affinity
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