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The primary concern, rapid drops in blood sugar from GLP-1 therapy can temporarily worsen existing DR, which is why it has been highlighted in research
Host: Peter Attia (@PeterAttiaMD) What Are GLP-1 Agonists
Key findings include: Dose-dependent improvements in neurological function scores at doses 2.5 ml/kg in rat models Reduced infarct volumes in middle cerebral artery occlusion (MCAO) models Enhanced functional recovery when combined with rehabilitation protocols Protection against excitotoxicity and oxidative stress in acute phase Studies using embolic stroke models showed that Cerebrolysin at 5 ml/kg significantly reduced lesion volume and improved sensorimotor outcomes when treatment began 4 hours post-stroke[8]
Many medications, particularly biologics, may not work as well in patients carrying extra weight
Yet, overproduction of reactive oxygen species (ROS), induced by environmental toxins, inflammation, or mitochondrial dysfunction, overwhelms the cellular antioxidant defense system, resulting in oxidative stress [27]
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