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GLP-2 does not increase the protein expression of FATP4 or MTP, rather it significantly increases the expression of glycosylated CD36

For a 220-pound person, this translates to roughly 33 pounds lost with semaglutide versus 11-18 pounds with Saxenda

Gupta A, Pahal S, Kumar V, Chaudhary A (2025) Role of monoclonal antibodies in Alzheimers disease: successes, failures, and future directions

If you do not lose at least 10% of your body weight in four months, it will provide a refund

The resulting lean mass loss, dehydration, and fatigue create a negative feedback loop that leads many to abandon the protocol entirely in the first month