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Preventive Services Task Force (USPSTF), the American Heart Association/American College of Cardiology/The Obesity Society (AHA/ACC/TOS), and the European Association for the Study of Obesity (EASO) each recommend multicomponent interventionsincluding caloric targets, physical activity, goal-setting, self-monitoring, and problem-solvingover a duration of at least six months to achieve clinically meaningful weight loss [35,36,37]

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It should be embedded into how care is designed, from diagnosis through follow-up

Abbreviations AT: As-treated CEA: Cost-effectiveness analysis CPI: Consumer price index CVD: Cardiovascular disease GDP: Gross domestic product GLA: Glucose-lowering agent GLP-1RA: GLP-1 receptor agonist HR: Hazard ratio ICER: Incremental cost-effectiveness ratio ITT: Intention-to-treated MACE: Major adverse cardiovascular event NHI: National Health Insurance NHIRD: National Health Insurance Research Database NNT: Number needed to treat OOP: Out-of-pocket QALY: Quality-adjusted life year T2D: Type 2 diabetes WTP: Willingness-to-pay References American Diabetes Association