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Preclinical studies reveal that CBDA exhibits distinct biological activity that is not fully replicated by CBD: Serotonin receptor modulation (5-HT1A agonism): CBDA demonstrates potent activity at 5-HT1A receptors, which may underlie its anti-nausea and anti-emetic effects observed in animal models

We acknowledge that there were some differences in the comparison between GLP-1RAs and other glucose-lowering agents, particularly concerning HbA 1c levels, the use of insulin and the use of SGLT2 inhibitors, which may have influenced the results

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