Special considerations regarding SGA use in adolescents While the connection between SGAs, weight gain and changes in gut microbiota is intriguing for populations of all ages, the child and adolescent patient groups require more careful attention
Because it slows gastric emptying, it may worsen gastrointestinal conditions
Clinical trials and meta-analyses consistently show that DPP-4 inhibitors produce a modest but clinically meaningful reduction in HbA1c , typically in the range of: 0.5% to 1.0% (approximately 5.5 to 11 mmol/mol) when used as monotherapy or add-on therapy Reductions at the higher end of this range are more likely when baseline HbA1c is significantly elevated For example, sitagliptin has demonstrated reductions of around 0.60.8% in randomised controlled trials, while vildagliptin and saxagliptin show broadly comparable efficacy

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Rorsman P, Ashcroft FM (2018) Pancreatic -cell electrical activity and insulin secretion: of mice and men