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Unbound lipoic acid When considering the biological activities of supplemental (unbound) lipoic acid, it is important to keep in mind the limited and transient nature of the increases in plasma and tissue lipoic acid (see Metabolism and Bioavailability) (3)

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Therefore, anesthesiologists must consider individual patient factors and medical history, the type of GLP-1 RAs used, the dosing regimen (daily vs