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Available evidence from diabetes and obesity trials demonstrates substantial weight regain after discontinuation of GLP-1 RAs, reaching pre-treatment levels in some cohorts within 12-18 months of cessation, with accompanying deterioration in cardiometabolic parameters [72]
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What other mechanisms may promote weight loss, and what factors would allow these agents to potentially compete with GLP-1 and GLP-1/GIP receptor agonists
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