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The pancreas also contains beta cells, which regulate how much insulin is produced

Individuals with certain genetic variants may exhibit enhanced sensitivity to GLP-1 therapy, potentially requiring lower semaglutide doses ($189/month starting price remains constant regardless of titration)

Conversely, persistent appetite, continued craving, or weight regain may indicate that psychological, behavioural, environmental, or treatment-exposure factors are overriding satiety-related effects, especially because weight regain can occur after treatment withdrawal or interruption (95)

When these symptoms become severe and other methods (like increased water intake, fiber, or exercise) havent worked, a laxative may provide relief