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Additionally, direct neuronglia communication is facilitated through two-way calcium signaling, primarily via purinergic P2 receptors (notably P2X7) and gap junctions (39)

Published literature documents stimulation of fibroblast proliferation, collagen and elastin synthesis, antioxidant gene upregulation, and modulation of transforming growth factor-beta signaling

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For context, many peptides show strong receptor activation in vitro but fail to produce clinical effects because they cannot be delivered at effective concentrations in living organisms