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For branded products approved to reduce weight in obesity, some also have expanded use to younger patients, and/or additional at-risk adult populations
Structurally, Ipamorelin is a synthetic pentapeptide ( Aib-His-D-2-Nal-D-Phe-Lys-NH2 , 711.9 Da) designed by NovoNordisk in collaboration with Ferring in the mid-1990s as a selective tool for the GHS-R1a receptor (Growth Hormone Secretagogue Receptor type 1a)
But upper respiratory tract infections, uncomfortable skin sensations and urinary tract infections were also listed as side effects in the trial results
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