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Incretins are endogenous compounds, including GLP-1, that improve glycemic control once released into the circulation via the gut
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The mechanisms underlying these effects involve mesenchymal stem cell proliferation and directed migration to injury sites, periosteum reactivation initiating new bone formation at attachment points, nitric oxide pathway modulation enhancing vascular tone and blood supply, and cytoprotective effects reducing tissue necrosis during the critical early inflammatory phase
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