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Research suggests 25-to-39 percent of weight lost on GLP-1s is fat-free mass, mostly muscle (Lieberman et al., JAMA 2026)
Resolution happens faster
For many, it reflects the body adjusting to reduced calorie intake and hydration changes
The 28-day timeline applies to Wegovy (single-dose) when stored at room temperature before use, not Ozempic
The titration protocol exists because GLP-1 receptor agonists cause gastrointestinal side effects, primarily nausea, that are dose-dependent
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