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Description

This is the mechanism that makes TB-500 relevant to injuries that involve slow or stalled healing: when the local repair response has exhausted its resources, TB-500 recruits fresh cells from the surrounding tissue and circulatory system into the damage zone

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It is the first membrane-permeable, selective inhibitor of nicotinamide N-methyltransferase (NNMT), developed at the University of Texas in 2017

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Ongoing studies on KL1s mechanism, along with medicinal chemistry optimization and in vivo testing in combination with diverse antibiotics against multiple pathogens, will be critical to determine the full therapeutic potential of this host-directed adjuvant in eradicating deep-seated infections

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