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The side effects of semaglutide are typically mild especially when compared to the complications associated with overweight and obesity

Legislative note: The Treat and Reduce Obesity Act, reintroduced in Congress in 2025, would remove the Medicare exclusion for obesity medications

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According to the World Health Organisation (WHO), obesity has nearly tripled, emphasising the urgent need for effective management strategies such as glucagon-like peptide 1 (GLP-1) analogues

As the GLP-1 medication class expands in 2026, new formulations and clinical data add nuance to headache management for patients on these therapies