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Nrf2 is involved in not only the regulation of GSH synthesis and reduction via upgrading some enzymes and proteins (SLC7A11, GCLM, GCLC, GR) but also the activation of GSH-dependent antioxidant enzymes (GPX, GST) [200, 201]

Glycemic control improves, although it is still too early to see weight loss

Diarrhea Diarrhea affects about 29.7% of semaglutide 2.4 mg users in the STEP trials versus 15.9% on placebo

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Marketed in the 1950s as a treatment for morning sickness, it caused thousands of birth defects before its withdrawalbecoming a symbol of regulatory failure