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For people with overweight or obesity and pre-existing cardiovascular disease (CVD), taking semaglutide for three years resulted in 20% fewer heart attacks, strokes, and deaths, compared to those taking a placebo, according to the new study

However, in clinical trials, Wegovy injection users were more more likely to experience GI issues than Mounjaro injection users: 44% of Wegovy users reported nausea compared to 12% of Mounjaro users 30% of Wegovy users reported diarrhea compared to 12% of Mounjaro users 24% of Wegovy users reported constipation compared to 6% of Mounjaro users 24% of Wegovy users reported vomiting compared to 5% of Mounjaro users Other common side effects for both medications include belching, fatigue, dizziness, and headaches

GLP1R agonists increase heart rate and might not be beneficial in individuals with severe left ventricular dysfunction, reduced ejection fraction and/or a history of repeated hospitalization for heart failure

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