Structural Changes of Gut Microbiota During Berberine-Mediated Prevention of Obesity and Insulin Resistance in High-Fat Diet-Fed Rats
Studies have found that in the retinal tissue of DR patients, high glucose can induce upregulation of NCOA4 expression, enhance ferritinophagy, reduce FtL, increase LC3-II/I, and activate NOX to produce ROS, forming a ROS ferritinophagy-free iron positive feedback loop (172)
An unbalanced excess of free oxygen radicals due to lack of antioxidants may increase the risk of coronary artery disease
This contributes to the synthesis of the amino acid tri-peptide, glutathione
At the same time, Trim37 deficiency increased global chromatin accessibility, with 27,919 upregulated peaks compared with 5215 downregulated peaks, particularly in regions associated with developmental genes (Fig