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In adipose tissue, HIF activation can improve IR by stimulating the thermogenic function of brown adipose tissue (BAT) by regulating mitochondrial biogenesis and glycolysis
Varied and balanced diet and optimal water intake are essential to get energy
Due to its roles in such a broad array of systems, targeting the ghrelin receptor with agonists or antagonists will not only affect the phenomenon of interest, such as feeding, but will also affect the other systems in which ghrelin is involved, leading to unwanted side effects
However, HGH can suppress natural GH production, may cause more side effects including glucose dysregulation, is greatly more expensive, and needs careful medical supervision
We are aware of no breakthrough or accelerated regulatory designation for a neurodegenerative indication in this class, and the recent Phase 3 failures are likely to make near-term regulatory filings in this space unlikely
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