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In this test, animals are placed in a pool of water from which they cannot escape or touch the bottom, typically exhibiting a state referred to as behavioral despair. The effectiveness of antidepressants is generally assessed in the FST by reducing the time spent in passive floating and increasing the time struggling and swimming, thus reflecting the potential antidepressant activity of the compounds

Feng, X., Zhang, L., Xu, S

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Con: Some people are hesitant to use a suppository at all, due to embarrassment or simply the awkwardness of using them

[PMID: 19036390] PubMed record related to this compound for laboratory literature review