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Furthermore, given the remaining questions around the innate magnitude and timing of acidbase/buffering changes in elite athletes at lowmoderate altitudes, let alone the potential adaptive impact of chronic exogenous buffers, we also cannot conclusively recommend the chronic use of NaHCO 3 or citrate supplementation

We use the profile-likelihood approach as presented in 48 to determine non-identifiable parameters and compute confidence intervals

Relax for a minimum of 1 hour to a maximum of 3 hours before removing the mask

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AF was the most potent inhibitor of TGR, with IC 50 values in the low nanomolar range