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Allow the vial to reach room temperature for 10 to 15 minutes before drawing each weekly dose.

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doi: 10.1038/s41392-021-00687-0 3 ColonnaM

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Participants were randomized 2:1:1:1:1:2:2 to receive placebo or retatrutide at 1 mg, 4 mg (starting at 2 mg), 4 mg (starting at 4 mg), 8 mg (starting at 2 mg), 8 mg (starting at 4 mg), or 12 mg (starting at 2 mg) administered subcutaneously once weekly for 48 weeks