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The SELECT cardiovascular outcomes trial (N=17,604), published in NEJM 2023 (DOI: 10.1056/NEJMoa2307563), demonstrated a 20% reduction in major adverse cardiovascular events (MACE) -- the composite of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke -- in overweight or obese adults without diabetes

Standard cycle structure: On cycle: 8-12 weeks of daily dosing Off cycle: 4 weeks without GHRP-6 (Mod GRF 1-29 can be continued during off-cycle if desired) Repeat Some researchers run longer cycles of 16-20 weeks, particularly when GHRP-6 is part of a structured peptide cycle

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The damaged proteins accumulate at points, which erupts on the skin's surface as scars, broken capillaries, wrinkles, etc

These medications are mostly taken through injection, though an oral version recently became available