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While there is some existing research on berberine as a standalone supplement, the evidence doesn't support the idea that it works as effectively as a prescription GLP-1 medication , and studies on the transdermal delivery method (absorbing supplements through the skin) for these ingredients are lacking

Graphical abstract Access this article Similar content being viewed by others Data availability The datasets generated during and/or analyzed during the current study are available from the corresponding author upon reasonable request

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A 2.5 mg dose is 0.25 mL